In this Deep Dive Session, Garrick Laudin, Nandipha Sigedle, and Jenifer Vaughan present on Acute Lymphoblastic Leukaemia (ALL). The discussion focuses on the genetic risk factors, particularly the translocation 1;19, its prevalence in people of African descent, and its implications on treatment outcomes. The session also emphasizes the need for local studies to understand the prognostic significance of this translocation in the African setting, and the importance of multidisciplinary meetings in planning therapy for ALL.