In this Deep Dive session, Dr Jacques Malherbe and Dr Tendayi Gutu provide a comprehensive overview of the management of chronic myeloid leukemia (CML), discussing the different treatment options, their side effects, and the importance of patient compliance. Emphasis is placed on the need for careful monitoring and individualized treatment plans, as well as the challenges and considerations in managing CML, including the role of risk assessment and the management of cytopaenias.